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Inflation has an important effect on economic, especially on industries performance. In most previous studies such as Banerjee & Brill russell (2005) and Anindya Banerjee and at el (2001), inflation has a negative effect on markup. In this paper the effect of inflation and globalization on big industries profit has been considered by panel data and vensim PLE during (2000-2007). Results show the level of liquidity and aggregate demand has a positive effect on inflation and the incomes of industries increase more than their costs in the inflationary condition so their profit increase. So inflation has a positive effect on the profit of industries which remain and produce in inflationary conditions, in contract of the done studies, and continue to their activities in Iran. The membership of Iran in WTO has been mentioned as a scenario in system dynamic model, which under this condition, because of decrease in tariff and non tariff obstacles and also importing of foreign goods with low prices, the industries will gradually became bankrupt.