Regional policy requires the use of a suitable economic model. One of the common patterns in this field is the multi-region input-output model in which the national economy is subdivided into regions with different comparative advantages and on the basis of specific policies. Multi-regional input-output data preparation in Iran has always been one of the main challenges in using them to measure the impact of policymaking in regions. In this study, in order to overcome the above challenge, the hybrid Location Quotient - Gravity method is introduced for the first time in Iran and has been empirically prepared for three regions of Iran. In hybrid Location Quotient - Gravity Method for Providing trade data between regions, utilizes the most space-economy factors (supplier size, demand size, total economy size, and distance) simultaneously. In the Experimental section, in order to operate the above method are used the National Input -output Table of 2011 and the statistics of regional accounts of provinces that are divided into three regions: Tehran, oil-rich regions (including Khuzestan, Bushehr, Ilam, Kohkiloyeh and Boyer-Ahmad and Trans-region) and have been calculated using three regional data-output coefficients. The results show that coefficients are different in the three study areas. Meanwhile, Tehran province has the most spillover effects among the study areas and the rest economy has the most coefficient.